Twist the web rubiks cube timer
It would be desirable to find a solution towards modular microfluidics that has both excellent performance and good usability so that it could fulfill the requirements for reliable and highly customizable microfluidic systems in resource-limited settings. In some cases, additional mechanical components such as metal connection pins 19 and screws 23 have been used to achieve higher pressure tolerance, but these components have also increased the complexity of the reconfiguration process and limited the usability of the system. The most common but critical problem is “leakage.” Owing to the unstable connections between discrete element blocks, fluids tend to leak under the effect of high pressure. Nevertheless, modular microfluidics has limitations when compared with monolithic microfluidics.
The modular microfluidics concept exhibits good adaptability in various applications and have become a promising approach for rapid on-site customization. In previous studies, microfluidic blocks were created in the form of jigsaw puzzle-like blocks 16, 17, Lego-like blocks 18, 24, 25, magnetic blocks 22, and other designs 19, 23 to allow the versatile combination of different components. Owing to this flexible design, modular microfluidics allows the design and reconfiguration of the microfluidics system during the postfabrication stage. In modular microfluidics, individual microfluidic blocks are created in a modular design and assembled to form a system. To enable the rapid deployment of customized microfluidic systems, the concept of “modular microfluidics” is proposed 16, 17, 18, 19, 20, 21, 22, 23, 24, 25. In applications such as device prototyping and point-of-care testing, where the rapid on-site customization and modification of the microfluidics platform are desirable 15, 3D printing becomes inefficient due to its lengthy cycle time from design to use. However, 3D printing can only yield monolithic devices, and the design of microfluidics must be done during the prefabrication stage. State-of-art 3D printing techniques have achieved channel cross-sections as small as 18 μm × 20 μm using desktop 3D printers 13 and even submicron scale microfluidic structures by two-photon polymerization 14, which are fine enough for most microfluidic applications. Among these, three-dimensional (3D) printing, the most representative approach known for its straightforward manner 11, 12, has been used to directly create arbitrary microfluidic structures. In recent years, the microfluidic community has witnessed the rapid development of novel fabrication techniques 9, 10 that are suited for the simplified customization of microfluidic systems.
#TWIST THE WEB RUBIKS CUBE TIMER PROFESSIONAL#
Although the emergence of soft lithography techniques and the use of elastomers have greatly simplified fabrication 8, such processes are still highly dependent on professional facilities and expert operators and therefore remain unreachable to many unequipped laboratories, not to mention the on-site deployment of microfluidics in resource-limited settings.
However, fabricating a custom microfluidic chip can be expensive, laborious, and very time consuming. That is, there is an increasing demand for customized microfluidic systems featuring various applications. Nevertheless, microfluidics technology is in its development stage, and the potential of microfluidics has yet to be fully exploited. Apart from the original use in chemical analysis 1, the unmatched advantages of microfluidics, such as low consumption of reagents, fast reaction speed, and high throughput 2, have brought forth endless possibilities in a large range of subjects, such as chemical synthesis 3, materials science 4, 5, biology 6, and clinical diagnosis 7. The usefulness of microfluidics cannot be overestimated in today’s scientific research.